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Table 1 Characterization of tight skin mice (TSK) phenotype of the pd-Fbn-1 transgenic mice

From: Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene

Mouse Strain Age N Skin Thickness ( µ m ) Hydroxyproline Content ( µ mol/ µ g dry tissue) Anti-Topo Ab (cpm) Anti-Fbn-1 Ab (cpm)
C57BI/6 3Mo 6 132 ± 42, P 518 ± 88, P 370 ± 441, P 2529 ± 2743, P
TSK/+ 3Mo 10 231 ± 89, 0.019 955 ± 361, 0.013 2266 ± 1187, 0.0022 11150 ± 5707, 0.004
Low 3Mo 7 161 ± 51, 0.286 565 ± 154, 0.528 583 ± 1149, 0.678 5576 ± 5199, 0.225
  6Mo 5 112 ± 33, 0.802 492 ± 134, 0.708 556 ± 663, 0.589 2509 ± 2337, 0.987
High 3Mo 4 158 ± 41, 0.26 732 ± 161, 0.032 411 ± 308, 0.878 9206 ± 10174, 0.155
  6Mo 6 203 ± 119, 0.199 897 ± 150, 0.017 1268 ± 887, 0.079 8445 ± 10535, 0.212
  1. Low, low copy number transgenic mice; High, high copy number transgenic mice; Fbn-1, mutated fibrillin-1 gene; pd Fbn-1, plasmid bearing Fbn-1; Anti-Topo Ab; cpm, counts per minute. Values are means ± standard error of the mean (SEM) P values compared experimental groups to C57BL/6.