Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene

Table 1 Characterization of tight skin mice (TSK) phenotype of the pd-Fbn-1 transgenic mice

Mouse Strain	Age	N	Skin Thickness ( µ m ⁾		Hydroxyproline Content ( µ mol/ µ g dry tissue)		Anti-Topo Ab (cpm)		Anti-Fbn-1 Ab (cpm)
C57BI/6	3Mo	6	132 ± 42,	P	518 ± 88,	P	370 ± 441,	P	2529 ± 2743,	P
TSK/+	3Mo	10	231 ± 89,	0.019	955 ± 361,	0.013	2266 ± 1187,	0.0022	11150 ± 5707,	0.004
Low	3Mo	7	161 ± 51,	0.286	565 ± 154,	0.528	583 ± 1149,	0.678	5576 ± 5199,	0.225
	6Mo	5	112 ± 33,	0.802	492 ± 134,	0.708	556 ± 663,	0.589	2509 ± 2337,	0.987
High	3Mo	4	158 ± 41,	0.26	732 ± 161,	0.032	411 ± 308,	0.878	9206 ± 10174,	0.155
	6Mo	6	203 ± 119,	0.199	897 ± 150,	0.017	1268 ± 887,	0.079	8445 ± 10535,	0.212

Low, low copy number transgenic mice; High, high copy number transgenic mice; Fbn-1, mutated fibrillin-1 gene; pd Fbn-1, plasmid bearing Fbn-1; Anti-Topo Ab; cpm, counts per minute. Values are means ± standard error of the mean (SEM) P values compared experimental groups to C57BL/6.

ISSN: 1528-3658