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Table 2 Characterization of tight skin syndrome in C57BL/6 mice immunized with plasmid expressing pdFbn-1 gene

From: Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene

Mouse Strain

Age

N

Skin Thickness µ m

Hydroxyprolin Content (µmol/µg dry skin)

Anti-Fbn-1 (cpm)

C57BL/6

12W

6

132 ± 42

P

518 ± 88

P

2529 ± 2743

P

TSK/+

12W

10

239 ± 89

0.0196

955 ± 361

0.013

11150 ± 5707

0.004

Sense

2W

12

144 ± 48

0.625

620 ± 31

0.58

29701 ± 9381

0.000018

4W

4

279 ± 82

0.0053

553 ± 45

0.540

13475 ± 11464

0.05

8W

3

230 ± 85

0.047

550 ± 30

0.640

9270 ± 2843

0.01

12W

9

157 ± 57

0.3741

630 ± 89

0.115

25246 ± 11319

0.00037

Anti-sense

2W

5

148 ± 29

0.54

558 ± 35

0.442

2693 ± 2357

0.9

4W

5

166 ± 50

0.245

503 ± 67

0.775

7434 ± 5689

0.0928

6W

4

123 ± 14

0.786

570 ± 42

0.405

2443 ± 1015

0.98

8W

3

151 ± 14

0.491

723 ± 23

0.006

2745 ± 1150

0.9

  1. Values are means ± standard error of the mean (SEM). P values compared experimental groups of C57BL/6. Fbn-1, mutated fibrillin-1 gene; pdFbn-1, plasmid bearing Fbn-1; TSK, tight skin mice Anti-Fbn-1 Ab,.