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Table 2 Characterization of tight skin syndrome in C57BL/6 mice immunized with plasmid expressing pdFbn-1 gene

From: Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene

Mouse Strain Age N Skin Thickness µ m Hydroxyprolin Content (µmol/µg dry skin) Anti-Fbn-1 (cpm)
C57BL/6 12W 6 132 ± 42 P 518 ± 88 P 2529 ± 2743 P
TSK/+ 12W 10 239 ± 89 0.0196 955 ± 361 0.013 11150 ± 5707 0.004
Sense 2W 12 144 ± 48 0.625 620 ± 31 0.58 29701 ± 9381 0.000018
4W 4 279 ± 82 0.0053 553 ± 45 0.540 13475 ± 11464 0.05
8W 3 230 ± 85 0.047 550 ± 30 0.640 9270 ± 2843 0.01
12W 9 157 ± 57 0.3741 630 ± 89 0.115 25246 ± 11319 0.00037
Anti-sense 2W 5 148 ± 29 0.54 558 ± 35 0.442 2693 ± 2357 0.9
4W 5 166 ± 50 0.245 503 ± 67 0.775 7434 ± 5689 0.0928
6W 4 123 ± 14 0.786 570 ± 42 0.405 2443 ± 1015 0.98
8W 3 151 ± 14 0.491 723 ± 23 0.006 2745 ± 1150 0.9
  1. Values are means ± standard error of the mean (SEM). P values compared experimental groups of C57BL/6. Fbn-1, mutated fibrillin-1 gene; pdFbn-1, plasmid bearing Fbn-1; TSK, tight skin mice Anti-Fbn-1 Ab,.