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Table 3 Summary of studies of tight skin mice (TSK) phenotype

From: Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene

    

Autoantibodies

Mice

Skin Thickness

Hydroxyproline Content

Lung Emphysema

Topol

Fbn-1

C57BL/6

N

N

−

−

−

TSK/+

I

I

+

+

+

pdFbn-1 Tg

I

I

−

+

−

C57Bl/6

T

I

−

−

+

+ plasmid

     
  1. N, normal; I, increased; T, transient; +, present; −, absent; Fbn-1, mutated fibrillin-1 gene; pdFbn-1 Tg, transgenic mice with plasmid bearing Fbn-1; topol, topoisomerase T.
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Molecular Medicine

ISSN: 1528-3658