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Table 3 Summary of studies of tight skin mice (TSK) phenotype

From: Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene

     Autoantibodies
Mice Skin Thickness Hydroxyproline Content Lung Emphysema Topol Fbn-1
C57BL/6 N N
TSK/+ I I + + +
pdFbn-1 Tg I I +
C57Bl/6 T I +
+ plasmid      
  1. N, normal; I, increased; T, transient; +, present; −, absent; Fbn-1, mutated fibrillin-1 gene; pdFbn-1 Tg, transgenic mice with plasmid bearing Fbn-1; topol, topoisomerase T.