Comparison of immunoreactivity patterns revealed by anti-PS2 antiserum (NT14) and a second amino-terminal PS2 anti-serum. A membrane identical to that used in Figure 2A was probed with an affinity-purified amino-terminal presenilin 2 (PS2) anti-serum (NT-PS2) previously described by Capell et al. (25). A second membrane, probed with affinity-purified NT14, is shown for comparison. PFC, prefontal cortex; L/PS1, L cell expressing human PS1; L/PS2, L cell expressing human PS2; N2a, Neuro-2a; N2a/PS2, N2a cell expressing human PS2; FL, full-length.