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Fig. 9 | Molecular Medicine

Fig. 9

From: Brain Expression of Presenilins in Sporadic and Early-onset, Familial Alzheimer’s Disease

Fig. 9

Western blot analysis of presenilin 1 (PS1) and presenilin 2 (PS2) expression in familial Alzheimer’s disease (FAD) cases. 200 µg of protein prepared from prefrontal cortex from control cases (lanes 1–3), sporadic AD cases (lanes 4 and 5), FAD cases caused by mutations within PS1 (lanes 6 and 7: M139I; lanes 8 and 9: H163R; lane 10: G209V; lane 11: A260V), and FAD cases caused by the N141I mutation within PS2 (lanes 12–14) were analyzed by Western blot as in Figure 7. An addition six PS1 FAD cases (M146I, two cases; and A246E, four cases) were analyzed with similar results.

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