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Fig. 7 | Molecular Medicine

Fig. 7

From: Advanced Glycation Endproducts: Activators of Cardiac Remodeling in Primary Fibroblasts From Adult Rat Hearts

Fig. 7

Effect of AGE-BSA on activity of metalloproteases. Quiescent confluent cardiac primary fibroblasts from the adult rat were incubated with 25 µM AGE-BSA or BSA for 24 hr. MMP activity was determined by Zymograms of cell culture supernatants as described in the methods section. (A) Analysis of MMP activity in gelatin and collagen zymograms. (B) Relative activation of MMPs by AGE-BSA as determined by densitometry of Zymograms. Shown are the means and the SEM of three independent experiments. *Significant in comparison to appropriate controls (p < 0.05).

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