Skip to main content

Table 1 Genetic factors affecting vertical transmission of HIV-1

From: Genetic Determinants of Pediatric HIV-1 Infection: Vertical Transmission and Disease Progression Among Children

Factor

Effect

Reference

HLA

HLA-A2

Protection

30

HLA-A3-B7-DR2

Protection

17,18

HLA-A1-B8-DR3

Higher risk

17,18

HLA-DQB1*0604

Higher risk

19

HLA-DR13 (DRB1*1301,*1302,*1303)

Protection

18

Chemokine receptors

CCR5-Δ32a

Protection

20

CCR5-59356-T

Higher risk

21

SDF1-3′A

Higher risk

22

  1. aSee Table 3 for more details on CCR5-Δ32 and risk of MTCT.
Back to article page

Molecular Medicine

ISSN: 1528-3658