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Table 2 Genetic factors implicated in HIV-1 disease progression among children

From: Genetic Determinants of Pediatric HIV-1 Infection: Vertical Transmission and Disease Progression Among Children

Factor

Effect

Reference

HLA

  

HLA-A*2301

Rapid progression

23

HLA-DPB1*0101

Survival

19

HLA-DPB1*0301

Slow progression

24

HLA-DR3 (DRB1*0301-DQA*0501-DQB1*0201)

Rapid progression

19,24

HLA-DR13 (*1301,*1302,*1303,*1310)

Survival

23

Chemokine receptors

  

CCR5-Δ32a

Slow progression

25–27

CCR2-64I

Slow progression

28

  1. aSee Table 3 for more details on CCR5-Δ32 and rate of HIV disease progression.
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Molecular Medicine

ISSN: 1528-3658