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Fig. 7 | Molecular Medicine

Fig. 7

From: Relationship of the K-ras/c-mos Expression Patterns With Angiogenesis in Non-Small Cell Lung Carcinomas

Fig. 7

Hypothetical model describing the effects of the K-ras/c-mos patterns on tumor neo-angiogenesis. Cases with mutated K-ras and/or stimulated growth factor (GF) autocrine loops (A and B, respectively) activate signaling cascades, such as MEK/ERK and PI3K pathways (8, and references therein), that lead to high VEGF levels and increased neo-angiogenesis. On the other hand, overexpression of c-mos regulates negatively the growth factor-dependent signaling cascades diminishing VEGF expression and tumor vascularization (42) (C).

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Molecular Medicine

ISSN: 1528-3658