Whole-mount preparations of Tg mice parenchymal vessels stained with thioflavine S (yellow fluorescence). Top panel shows the Tg2576 mouse. Bottom panel corresponds to the APP23 Tg mouse. There is an overwhelming amount of vascular amyloid in the APP23 Tg mouse when compared to the Tg2576 mouse. The walls of most of the vessels are loaded with amyloid deposited along the perpendicularly oriented smooth muscle cells.