Fig. 6

Evidence of cell shrinkage 24 hours following H-I is present in both Bax +/− and Bax −/− mice. Cell shrinkage occurred in the left hemisphere 24 hours following H-I ipsilateral to the carotid ligation. Hippocampal sections were stained with cresyl violet and examined at low power (A, B, E, F) and high power (C, D, G, H) in bax +/− (A–D) and bax −/− mice (E–H). In the CA1 region (C, D, G, H), shrunken nuclei with condensed chromatin (arrow) were present in both bax +/− (D) and bax −/− (H) mice but were generally less prominent in bax −/− mice. Scale bar in F for A, B, E, and F, 50 µm. Scale bar in H for C, D, G, and H, 20 µm.