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Fig. 3 | Molecular Medicine

Fig. 3

From: Interferon-γ-Induced Oligodendrocyte Cell Death: Implications for the Pathogenesis of Multiple Sclerosis

Fig. 3

Effect of IFN γ on the survival of sensory neurons

DRG neurons were cultured in the presence of NGF on a polyornithine/laminin substratum. After 2 weeks, in vitro cultures were exposed to control solution, or IFNγ for 7 days. Viability was assessed with MTT conversion to an insoluble purple precipitate shown above. There is a small decrease in the number of viable sensory neurons, which does not reach a statistical significance (controls, 126 ± 16 versus IFNγ, 103 ± 9.7) morphology and neuritic outgrowth from IFNγ treated neurons is indistinguishable from controls. Bar = 10 µm.

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Molecular Medicine

ISSN: 1528-3658