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Fig. 6 | Molecular Medicine

Fig. 6

From: Interferon-γ-Induced Oligodendrocyte Cell Death: Implications for the Pathogenesis of Multiple Sclerosis

Fig. 6

Identification of apoptotic oligodendrocytes and IFN γ -positive cells at the margins of chronic active MS lesions

Cryostat sections of fresh frozen tissue from MS patients (17) were processed for colabeling apoptotic nuclei (brown) and MOG (purple/black), (a and b), human IFNγ (d and e), and oil-O-red to identify active phagocytic cells (c). Panels a–d show a chronic active MS lesion, whereas Panel e shows a region of unaffected white matter from the same patient. The tissue was removed at autopsy performed 4 hr after death and frozen. Some freezing artifacts are apparent on the sections.

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