Fig. 7

Quantitation of apoptosis in the center and at the margin of the chronic active MS lesion shown in Fig. 6

Ten nonoverlapping 200X fields that comprised approximately half of the area occupied by the chronic center of the lesion and eight nonoverlapping contiguous 200X fields that comprised the majority of area occupied by the active margin were averaged. In addition, 10 random fields within unaffected white matter were counted. Apoptotic oligodendrocytes (filled bars) and apoptotic cells which did not colabel for the oligodendrocyte-specific protein MOG (hatched bars) were counted.