Table 5 JH gene segment usage in VH3 + IgM antibodies
Donors | Specificity | No. of Clones | Frequency (%) | |||||
|---|---|---|---|---|---|---|---|---|
JH1 | JH2 | JH3 | JH4 | JH5 | JH6 | |||
Normal controls | RF− | 33 | 3.0 | 6.1 | 6.1 | 54.5 | 15.2 | 15.2 |
RA patients | RF− | 34 | 0.0 | 2.9 | 5.9 | 55.9 | 8.8 | 26.5 |
RF+ | 31 | 0.0 | 3.2 | 3.2 | 71.0 | 3.2 | 19.4 | |
pSS patients | RF− | 24 | 4.2 | 0.0 | 16.7 | 50.0 | 12.5 | 16.7 |
RF+ | 23 | 0.0 | 13.0 | 17.4 | 52.2 | 4.3 | 13.0 | |