Table 6 DH gene segment usage in VH3 + IgM antibodies
Donors | Specificity | No. of Clones | Frequency (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
DXP | DA | DLR | DK | DN | DM | DHF16 | DIR | DHQ52 | Unknown | |||
Normal controls | RF− | 33 | 39.4 | 0.0 | 21.2 | 6.1 | 18.2 | 12.1 | 0.0 | 9.1 | 0.0 | 6.1 |
RA patients | RF− | 34 | 38.2 | 2.9 | 11.8 | 17.6 | 20.6 | 0.0 | 5.9 | 2.9 | 0.0 | 8.8 |
RF+ | 31 | 35.5 | 6.5 | 6.5 | 22.6 | 16.1 | 3.2 | 9.7 | 0.0 | 0.0 | 6.5 | |
pSS patients | RF− | 24 | 54.2 | 0.0 | 8.3 | 8.3 | 4.2 | 4.2 | 4.2 | 4.2 | 0.0 | 20.8 |
RF+ | 23 | 30.4 | 4.3 | 34.8 | 13.0 | 8.7 | 0.0 | 8.7 | 0.0 | 0.0 | 4.3 | |