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Table 1 Analysis of secretory granule content in corticotrophic and thyrotrophic cells before and after endotoxin administration

From: Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland

Granule Content Time
0 hr 16 hr
Corticotrophes   
MIF alone (%) 8.1 ± 3.9 4.9 ± 4.4 (p < 0.05)
MIF + ACTH (%) 24.4 ± 17.5 15.1 ± 5.8 (p = NS)
ACTH alone (%) 67.5 ± 18.3 80.0 ± 9.2 (p = NS)
Thyrotrophes   
MIF alone (%) 20.1 ± 10.1 8.6 ± 4.4 (p < 0.05)
MIF + TSH (%) 13.7 ± 9.1 9.1 ± 5.0 (p = NS)
TSH alone (%) 66.3 ± 13.4 82.3 ± 8.2 (p = NS)
  1. Cells were stained with anti-MIF-anti-ACTH- and anti-TSH-labeled gold particles and quantified as described in the legend to Fig. 7 and Materials and Methods.