Fig. 2From: Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation CNS histopathology of animals treated with anti-IL-6 EAE was acitvely induced by immunizing SJL/J mice s.c. with MSCH in CFA and by giving pertussis toxin i.v. Animals received 1 mg anti-IL-6 (20F3) mAb or the same volume of PBS i.p. on Day −1 relative to EAE induction, and were sampled when the PBS-treated group showed disease signs. (A) Cerebellum of a PBS-treated animal with numerous perivascular inflammatory infiltrates (arrowheads) in the white matter. (B) same area of an anti-IL-6-treated animal, no infiltrate is present. (Giemsa staining, 10×, original magnification).Back to article page