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Fig. 2 | Molecular Medicine

Fig. 2

From: Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation

Fig. 2

CNS histopathology of animals treated with anti-IL-6

EAE was acitvely induced by immunizing SJL/J mice s.c. with MSCH in CFA and by giving pertussis toxin i.v. Animals received 1 mg anti-IL-6 (20F3) mAb or the same volume of PBS i.p. on Day −1 relative to EAE induction, and were sampled when the PBS-treated group showed disease signs. (A) Cerebellum of a PBS-treated animal with numerous perivascular inflammatory infiltrates (arrowheads) in the white matter. (B) same area of an anti-IL-6-treated animal, no infiltrate is present. (Giemsa staining, 10×, original magnification).

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