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Fig. 9 | Molecular Medicine

Fig. 9

From: Differences in the Expression of Heat-Shock Proteins and Antioxidant Enzymes between Human and Rodent Pancreatic Islets: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

Fig. 9

Effects of streptozotocin on rat and human islet apoptosis

Rat and human islets were treated with different concentrations of streptozotocin for 2 or 24 hr. Apoptotic cells are characterized by condensed and dark-brown nuclei. (A) Control rat islets with an accumulation of centrally located apoptotic nuclei. (B) Rat islets treated with 12 mM streptozotocin for 2 hr. A few apoptotic cells can be observed centrally within one large islet. (C) Rat islets treated with 0.5 mM streptozotocin for 24 hr. Disrupted islets with a high proportion apoptotic cells can be seen. (D) Human control islets. (E) Human islets exposed to 12 mM streptocotocin for 2 hr. (F) Human islets exposed to 2 mM streptocotocin for 24 hr. In all three human islet preparations (D–F), there are only a few or no apoptotic cells.

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