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Fig. 7 | Molecular Medicine

Fig. 7

From: Parallel Induction of Heme Oxygenase-1 and Chemoprotective Phase 2 Enzymes by Electrophiles and Antioxidants: Regulation by Upstream Antioxidant-Responsive Elements (ARE)

Fig. 7

Sequences of the SX2 region and its mutations

(A) Sequence of the SX2 element of the 5′-upstream region of the mouse HO-1 gene showing the region of −268 to −29 bp from the origin of replication. The locations of three potential TRE/ARE and two C/EBP regulatory regions are shown. (B) The five above-mentioned regulatory regions present in the SX2 sequence are shown together with the base changes that were introduced to provide the mutants designated SX2M2, SX2M4, SX2M789, and SX2M239. The consensus TRE and ARE sequences are shown for comparison.

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