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Fig. 1 | Molecular Medicine

Fig. 1

From: Insulin-like Growth Factor I and Urokinase-type Plasminogen Activator Bioregulation System as a Survival Mechanism of Prostate Cancer Cells in Osteoblastic Metastases: Development of Anti-Survival Factor Therapy for Hormone-Refractory Prostate Cancer

Fig. 1

Cell-to-cell interactions involving metastatic prostate cancer and osteoblasts in the microenvironment of osteoblastic metastases.

Note the pivotal role of urokinase-type plasminogen activator (uPA)/insulin-like growth factor-binding proteins (IGFBPs)/IGF-1 bioregulation system, which is capable of affecting both the growth of metastatic cancer cells and osteoblasts (blastic reaction). In addition, note the potential regulation of IGFs at the site of osteoblastic metastases by growth hormone (GH). GHRH, GH-releasing hormone; hK2, human kallikrein 2.

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