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Fig. 4 | Molecular Medicine

Fig. 4

From: Myocardial Postischemic Injury Is Reduced by PolyADPribose Polymerase-1 Gene Disruption

Fig. 4

Immunohistochemical staining for PAR in rat hearts subjected to in vivo regional I/R with left anterior descending coronary artery (LAD) ligation and 10 min reperfusion.

Myocardium of sham-treated animals exhibits basal levels of PAR staining [PAR (SHAM)] and robust accumulation of PAR in the ischemic risk region of the left ventricle is seen after I/R [PAR (I/R)]. Treatment of rats with the PARP inhibitor, 3-aminobenzamide, prior to reperfusion [PAR (I/R, 3-AB)] reduces in vivo-accumulated PAR to levels below the accumulation of PAR seen in shamtreated hearts. I/R, ischemia-reperfusion; PAR, polyADPribose.

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