Lisinopril dose-effect on angiotensin I-converting enzyme (ACE) activity.
Activity in plasma (A), exudate (B), and exudate volume (C) after 10 days carrageenan-induced inflammation in F344/N rats. LEW/N rats were used as a control of exudation. Three doses of 0.5, 3, and 10 mg/kg body weight lisinopril or saline treatment (i.p.) were performed 3 hr before carrageenan injection and continued twice a day for 10 days. ACE activity was measured against the synthetic substrate 3H-hippuryl-glycylglycine (3H-HGG) and corrected by the total protein (nmol/min/mg protein). Data are expressed as mean ± SD (n = 3–5 per group). * = p < 0.0001 saline- or lisinopril-treated F344/N versus saline-treated LEW/N rats. ** = p < 0.0001 lisinopril-treated F344/N versus saline-treated F344/N rats.