Effect of LLYAQDLEDN on expression of delayed-type hypersensitivity by immunized mice.
Mice were sensitized to ferritin by immunization with ferritin in Freund’s complete adjuvant (FCA) and to Herpes simplex virus (HSV) by infection with sublethal doses of virulent human HSV-1. Treatment with LLYAQDLEDN did not inhibit expression of delayed-type hypersensitivity (DTH) in either group. For ferritin-immune mice the footpad response was 68.17 ± 11.66 × 10−2 mm; for ferritin-immune, LLYAQDLEDN-treated mice, footpad response was 75.00 ± 7.76 × 10−2 mm (p > 0.60). Mice that were sensitized to HSV by sublethal infection developed footpad responses to irradiated HSV of 24.80 ± 3.17 × 10−2 mm. The identically infected, LLYAQDLEDN-treated mice had footpad responses of 27.80 ± 3.98 × 10−2 mm (p > 0.50).