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Table 2 Inhibition of transfer factor activity by synthetic peptides

From: Transfer Factors: Identification of Conserved Sequences in Transfer Factor Molecules

Sequence

Relative Inhibitory Activity

LLYAQDLEDN (10−4 M)

100%

LLYAQDLED (10−4 M)

8

LYAQDLEDN (10−4 M)

0

LYAQDLEDN (10−3 M)

42

YAQDLEDN (10−4 M)

13

LLAYQDVEDN (10−4 M)

66

LLYAQDLEDN (10−6 M)

57

LAYAQKLEAN (10−4 M)

9

  1. Each mouse received 1.0 ml of a solution containing the stated concentration of peptide. Note that when the concentration of LYAQDLEDN was increased 10-fold, significant (0.05 > p > 0.02) inhibition of the activity of the transfer factor was seen. The inhibitory activity of 10−4 M LLYAQDVEDN was not significantly different from that of 10−6 M LLYAQDLEDN (p > 0.20).
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Molecular Medicine

ISSN: 1528-3658