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Fig. 1 | Molecular Medicine

Fig. 1

From: Functional Characterization of Three Mutations of the Endothelin B Receptor Gene in Patients With Hirschsprung’s Disease: Evidence for Selective Loss of Gi Coupling

Fig. 1

Representation of the three mutant hETB receptors. Locations of the three mutations in a schematic representation of ETB and sequence homologies between species—Comparisons of human (44), rat (45), mouse (10), bovine (46), and horse (47) ETB sequences using the programme MacVector. Sequences around the R319W and P383L mutations are highly conserved among species, whereas those around the G57S mutation are not.

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