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Fig. 2 | Molecular Medicine

Fig. 2

From: Functional Characterization of Three Mutations of the Endothelin B Receptor Gene in Patients With Hirschsprung’s Disease: Evidence for Selective Loss of Gi Coupling

Fig. 2

Characterization of the recombinant CHO cell lines permanently bearing the WT or mutant hETB receptors. The binding assay was performed on intact cells using 100-pM labeled 125I ET-1. 125I ET-1 binding to CHO cells bearing the WT hETB receptor (d), or the mutant hETB receptors G57S (□), R319W (△) and P383L (◇) was displaced with various concentrations of unlabeled ET-1. Results are expressed in counts per minute (cpm) and correspond to the means 6 SEM of triplicates.

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Molecular Medicine

ISSN: 1528-3658