Skip to main content
Fig. 7 | Molecular Medicine

Fig. 7

From: Functional Characterization of Three Mutations of the Endothelin B Receptor Gene in Patients With Hirschsprung’s Disease: Evidence for Selective Loss of Gi Coupling

Fig. 7

Effects of ET-1 on cAMP accumulation in HEK-293 cells bearing WT or mutant hETB receptors. (A) Cells bearing WT receptor (d) or mutant hETB receptors G57S (□) and R319W (△) were treated with increasing concentrations of ET-1. (B) Cells with WT receptor (d) or mutant hETB receptors G57S (□) were treated with increasing concentrations of ET-1 without (lines) or with pertussis toxin (dots). The intracellular contents of cAMP were determined as in Fig. 6.

Back to article page

Molecular Medicine

ISSN: 1528-3658