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Fig. 3 | Molecular Medicine

Fig. 3

From: α 1 Na,K-ATPase and Na,K,2Cl-Cotransporter/D3mit3 Loci Interact to Increase Susceptibility to Salt-Sensitive Hypertension in Dahl SHSD Rats

Fig. 3

Nucleotide sequence analysis of NKC gene. (a) Diagram depicting intro/exon organization of the alternative spliced exons (4B, 4A, and 4F) region within the NKC gene. Relative positions of the mutations (M1, M2, M3, and M4) detected in this study are shown within intron 3 (4.65 kb). Nucleotide sequence analysis of intron 3 revealed the following mutations: M1, (T)23/(T)22 nucleotide insertion/deletion (Dahl R/Dahl S) at position 1040 in (b); M2, (AC)21/(AC)20 dinucleotide insertion/deletion (Dahl S/Dahl R) at position 1987 in (c); M3, G/A nucleotide transition (Dahl R/Dahl S) at position 3285 in (d); and M4, (AC)18/(AC)17 dinucleotide insertion/deletion (Dahl R/Dahl S) at position 3852 in (e).

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