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Table 3 Summary of the effects of D3T on the induction of hepatic murine genes in wild-type and nrf2 -disrupted mice

From: Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2-Dithiole-3-thione

 

Genotype

 
 

+/+

−/−

Examples

O

↑

—

GST Ya, QR, mEH, yGCSr

U

T

↑

↑

GST Yp

C

↑

↓

UGT1A6, HQ1, MnSOD

O

M

—

↑

Ferritin H & L

E

—

↓

GST Yc, AFAR, catalase

S

—

—

Albumin