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Fig. 1 | Molecular Medicine

Fig. 1

From: Interleukin-6 and Glucocorticoids Synergistically Induce Human Immunodeficiency Virus Type-1 Expression in Chronically Infected U1 Cells by a Long Terminal Repeat Independent Post-Transcriptional Mechanism

Fig. 1

Synergistic induction of HIV expression by IL-6 and Dex in U1 cells. (A) Kinetics of RT activity produced in culture supernatants after an individual stimulation with IL-6, Dex, or co-stimulation with both agents. The results show the mean ± SD of 10 independent experiments. (B) RU 486 blocks the synergistic induction of HIV expression in U1 cells co-stimulated with Dex and cytokines. The results represent peak RT activities measured 4 days after treatment, and were confirmed by determinations performed at day 6. In some experiments, hydrocortisone instead of Dex was used in the same range of concentrations with identical results.

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Molecular Medicine

ISSN: 1528-3658