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Fig. 3 | Molecular Medicine

Fig. 3

From: Interleukin-6 and Glucocorticoids Synergistically Induce Human Immunodeficiency Virus Type-1 Expression in Chronically Infected U1 Cells by a Long Terminal Repeat Independent Post-Transcriptional Mechanism

Fig. 3

Northern blot analysis of HIV-1 and MCP-1 RNA. Total RNA was extracted from unstimulated and stimulated U1 cells after 48 h of culture for HIV RNA, and after 5 h of culture for MCP-1. (A) As reported (32), Dex upregulated the expression of HIV RNA in U1 cells following cell incubation with TNF-α, whereas it did not alter the low levels of transcripts observed in this cell line either left unstimulated or stimulated with IL-6. (B) IL-6 activates MCP-1 expression in U1 cells (41) and this effect is inhibited by Dex.

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Molecular Medicine

ISSN: 1528-3658