Unique site analysis of falcipain-2 in the context of human homologs. Cathepsins B, C, H, K, L, L2, O, S, Z and stefin B were the human homologs used in this evolutionary analysis. In green are residues unique in falcipain-2 relative to the human sequences. Other colors correspond to the defined specificity sites as represented in Figure 2. See Methods for definition of the specificity sites and the unique site analysis. This figure was generated with a sequence to structure alignment JAVA™ application (M.P. Joachimiak, in preparation), CHIMERA (18) and MSMS (29).