Table 2 Chemical structures and properties of prescribed antimalarial drugs
From: The Impact of Whole Genome Sequence Data on Drug Discovery—A Malaria Case Study
Name | Resistance [32] | Toxicity [32] | Compound |
|---|---|---|---|
quinine | Yes | delayed ‘glaucoma’ |
|
chloroquine | Yes | heart liver |
|
hydroxychloroquine | Yes | retina macula |
|
primaquine | Yes | anemia |
|
amodiaquine | like chloroquine | agranulocytosis with long term treatment |
|
mefloquine | Yes | cardiotoxicity, vivid dreams, psychosis |
|
proguanil | Yes DHFR | ulcers, alopecia |
|
atovaquone (with proguanil) | Yes selective cytochrome b | minor |
|
pyrimethamine (with sulfadoxine or sulfonylbisbenzenamine) | Yes DHFR | severe skin disease |
|
sulfadoxine (with pyrimethamine) | Yes | severe skin disease |
|
sulfonylbisbenzenamine (with pyrimethamine) | anemia, allergy, fever |
| |
doxycycline (with quinine) | sun sensitivity |
| |
Artemisinin | CNS toxicity |
| |
halofantrine | cardiotoxicity |
| |
Pyronaridine | teratogen |
|
