|  | NOD (n = 5) |  | db/db (n = 5) | ||
---|---|---|---|---|---|---|
Treatment (LZ) | SJL (n = 10) | Baseline | 2-Weeks | db/m (n = 10) | Baseline | 2-Weeks |
Weight (g) | 25 ± 3 | 25.3 ± 2.4 | 26.8 ± 1.6 | 26.7 ± 2.8 | 48.9 ± 1.5 | 50.1 ± 1.6 |
Blood glucose (mg/dL) | 117 ± 44 | 128 ± 20 | 132 ± 32 | 121 ± 27 | 320 ± 130 | 290 ± 60 |
Serum AGE (U/ml) | 14.2 ± 4.8 | 31.5 ± 6.7 | 22.3 ± 5.1* | 21.5 ± 7.7 | 37.9 ± 3.8 | 26.2 ± 5.3* |
Serum Cr (mg/dL) | 0.38 ± 0.04 | 0.42 ± 0.02 | 0.47 ± 0.05 | 0.33 ± 0.06 | 0.69 ± .01# | 0.72 ± 0.11## |
Urine AGE (U/ml) | 197 ± 41 | 200.3 ± 71.4 | 367.9 ± 41.2* | 103.8 ± 37.5 | 92.7 ± 52.6 | 170.9 ± 49.5* |
Urine Cr (ug/ml) | 357.3 ± 77.9 | 308.4 ± 68.7 | 324.9 ± 50.3 | 276.5 ± 93.4 | 207.6 ± 31.7 | 212.3 ± 49.4 |
Ccr (ml/min) | 0.03 ± 0.01 | 0.04 ± 0.008 | 0.05 ± 0.007 | 0.05 ± 0.02 | 0.05 ± 0.007 | 0.05 ± 0.01 |
CAGE (ml/min) | 0.004 ± 0.0012 | 0.003 ± 0.0011 | 0.008 ± 0.0009** | 0.003 ± 0.001 | 0.004 ± 0.002 | 0.013 ± 0.004** |
Urinary Alb/Cr | 0.29 ± 0.15 | 0.92 ± 0.32## | 0.53 ± 0.24* | 0.38 ± 0.2 | 1.13 ± 0.45 | 0.73 ± 0.26* |