Fig. 4From: Arsenite Activation of PI3K/AKT Cell Survival Pathway is Mediated by p38 in Cultured Human KeratinocytesSequence of events upon arsenite exposure of human keratinocytes. Arsenite induces phosphorylation of AKT and eNOS that is mediated by PI3K and p38. Activation of PI3K and p38 after arsenite treatment may be due to the imbalance between cellular kinases and phosphatases and the membranous activity that may or may not involve cell surface receptors.Back to article page