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Fig. 6 | Molecular Medicine

Fig. 6

From: Immunological Detection of a Novel Advanced Glycation End-Product

Fig. 6

Alternative routes for the formation of immunochemically distinct AGEs in vivo. Advanced glycation end-products (AGEs) arise from the decomposition of Amadori products (AGE-1), the glycolysis intermediate product glyceraldehyde (AGE-2), the Schiff base fragmentation product glycolaldehyde (AGE-3), the triose phosphate and the Amadori product fragmentation product methylglyoxal (AGE-4), the autoxidation product of glucose glyoxal (AGE-5), and decomposition product of Amadori products and fructose-3-phosphate to 3-DG (AGE-6). CML, N-(carboxymethyl)lysine; CEL, N-(carboxyethyl)lysine; â“Ÿ-NH2, free amino residue of protein (AR, aldose reductase; SDH, sorbitol dehydrogenase; 3-PK, fructose-3-phosphokinase; ALR, aldehyde reductase; GO, glyoxalase; MOG, mono-oxygenase).

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