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Fig. 2 | Molecular Medicine

Fig. 2

From: Diabetes and the Role of Inositol-Containing Lipids in Insulin Signaling

Fig. 2

Schematic indicating a possible route through which insulin could stimulate IPG type-A generation in normal insulin-responsive cells. Points within the proposed route at which a blockade would result in the formation of insulin-resistant cells are indicated. (1) Insulin receptor protein tyrosine kinase (point-mutated, kinase domain-deleted, serine/threonine hyperphosphorylation). (2) IRS proteins (expression levels, phosphorylation state). (3) Phospholipases C (PLC) or D (PLD) (expression levels, coupling). (4) GPI in the plasma membrane (quantity, localization). (5) IPG type-A transporter/receptor IPG type-A signal “transducing protein” (expression levels, functionality). The open symbols represents IPG derived from GPI-PLD-mediated GPI hydrolysis. The closed symbols represent IPG derived from GPI-PLC-mediated GPI hydrolysis.

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