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Fig. 3 | Molecular Medicine

Fig. 3

From: Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1

Fig. 3

Subcellular localization of PS1-CTF and -NTF in nontransgenic hippocampal neurons. Cultures examined at stage 1 (A), stage 2 (B), stage 3 (C), stage 4 (D), and stage 5 (E) with the PS1 C-terminal-specific antibody 17.2 showed the perinuclear labeling, as well as labeling within the processes, which extends to the growth cones. Comparable immunofluorescence was obtained with the N-terminal-specific Ab14 as shown in the fully differentiated cells (F). Arrows indicate the PS1 immunoreactivity that was observed at the termini of the expanding processes.

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