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Fig. 4 | Molecular Medicine

Fig. 4

From: Developmental Expression of Wild-Type and Mutant Presenilin-1 in Hippocampal Neurons from Transgenic Mice: Evidence for Novel Species-Specific Properties of Human Presenilin-1

Fig. 4

Colocalization of PS1 with markers to the endoplasmic reticulum (ER) and CGN compartments. Differentiated neurons (stage 5) were double labeled with a monoclonal antibody to the ER protein, BiP (A), and the PS1 C-terminal fragment using the 17.2 antiserum (B) with a color overlay (C), with BiP in green and PS1 in red. Similar cultures were examined with the CGN marker, p58 (D) and the 17.2 antiserum (E) to demonstrate the degree of overlap between the two proteins. A color overlay with p58 in green and PS1 in red is shown in F.

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