Fig. 1

Distribution of cerebral blood flow during ischemia in wild-type (WT) and HO2^−/− mice. (Top) Digitized image of regional cerebral blood flow during focal ischemia in a WT and HO2^−/− mouse determined by autoradiography of the iodoantipyrine tracer. (Bottom) Histogram depicting the relative volume of tissue in ischemic hemisphere partitioned into ranges of cerebral blood flow from WT (n = 5) and HO2^−/− (n = 5) mice. There is no significant difference in blood flow distribution. Under similar conditions using laser-Doppler flowmetry measured over ischemic cortex, we observed a rapid decrease in red cell flux (approximately 85%) during the occlusion and a complete recovery to baseline after the filaments were withdrawn. No differences could be quantified between the WT and HO2^−/− mice.