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Table 3 Expression of HMB-synthase mutation M212V in E. coli

From: Identification and Expression of Mutations in the Hydroxymethylbilane Synthase Gene Causing Acute Intermittent Porphyria (AIP)

Construct HMB-synthase activity (U/mg/hr) Percent of mean normal expressed activity
Mean a Range
JM109 0.2 0.1–0.3 0.0
pKK-HMBS 75.0 67.8–83.2 100.0
pKK-HMBS-M212V 1.3 1.1–1.7 1.7
  1. aMean and range based on results of three independent experiments.