Fig. 3
From: NO-Evoked Macrophage Apoptosis Is Attenuated by cAMP-Induced Gene Expression
Long-term lipophilic cAMP treatment decreased cytochrome c release and Bcl-XL down-regulation. RAW 264.7 macrophages, preincubated with 1 mM db-cAMP for 15 hr, were exposed to 1 mM GSNO or 0.25 mM Sp-NO for 6 hr. Translocation of cytochrome c (A) and expression of Bcl-xL (B) were analyzed by Western blot analysis as described in Materials and Methods. Western blots are representative of three similar experiments.