Fig. 2From: Cysteinyl Leukotrienes Mediate Histamine Hypersensitivity Ex Vivo by Increasing Histamine Receptor NumbersEffects of FCS on histamine hyperresponsivity in human umbilical smooth muscle cells. Cells were stimulated with different concentrations of histamine in the absence (open circles) or presence (filled circles) of 5% FCS for 1 hr. The histamine-induced PGE2 production was used as a functional measure to determine the histamine responses in these cells. Results represent the mean and standard error of three independent experiments. Statistically significant differences were calculated using the Mest; **p < 0.01.Back to article page