Table 1 Cell cycle-related targets of ubiquitin-mediated proteolysis

Cell cycle kinases and their regulators

Cyclin D1

G₁ cyclin

Hs

SCF

Cyclin E

G₁ cyclin

Hs

SCF

Clnl

G₁ cyclin

Sc

SCF

Cln2

G₁ cyclin

Sc

SCF

Cln3

G₁ cyclin

Sc

SCF

Clb5

S-phase cyclin

Sc

APC

NIME

Mitotic cyclin

An

APC

Clb2

Mitotic cyclin

Sc

APC

Clb3

Mitotic cyclin

Sc

APC

Cdc13

Mitotic cyclin

Sp

APC

Cyclin A

Mitotic cyclin

Ss

APC

Cyclin B1

Mitotic cyclin

Xl

APC

Cyclin B3

Mitotic cyclin

Xl

APC

p21

CDK inhibitor

Hs

SCF

p27

CDK inhibitor

Hs

Ubc2/Ubc3

Farl

CDK inhibitor

Sc

SCF

Sicl

CDK inhibitor

Sc

SCF

Swel

CDK inhibitor

Sc

SCF

Ruml

CDK inhibitor

Sp

SCF

NIMA

Mitotic kinase

An

APC

Plkl

Mitotic kinase

Hs

APC

Cdc5

Mitotic kinase/APC regulator

Sc

APC

Weel

Mitotic inhibitory kinase

Xl

SCF

Cdc25

Mitotic phosphatase

Sp

Public

Regulators of DNA replication

Cdc6

Replication initiation

Sc

SCF

Cdc18

Replication initiation

Sp

SCF

Geminin

Replication inhibitor

Xl

APC

Factors required for mechanics of cell duplication and division

Pdsl

Sister chromatid separation

Sc

APC

Cut2

Sister chromatid separation

Sp

APC

P58ctf13

Kinetochore assembly

Sc

SCF

Asel

Mitotic spindle component

Sp

APC

Gicl

Cytoskeletal rearrangement

Sc

SCF

Gic2

Cytoskeletal rearrangement

Sc

SCF

Regulators of transcription

DPI

Transcription factor/E2F partner

?

E2F-1

Transcription factor

Hs

SCF

Fos

Transcription factor

Hs

?

Jun

Transcription factor

Hs

?

Myc

Transcription factor

Hs

?

p53

Transcription factor

Hs

?

Mdm2

p53 antagonist

Hs

?

Components of proteolytic machinery and their regulators

Cdc20

APC regulator

Sc

APC

Cdc4

SCF component

Sc

SCF

Grrl

SCF component

Sc

SCF