PBMC from | Untreated | + SNAPa | Apoptosisb (%) |
P
c
|
---|
AIDS <300 CD4+ cells/mm3 (×10) | 59 ± 12 | 34 ± 13 | +43 | <0.0001 |
AIDS >300 CD4+ cells/mm3 (×7) | 56 ± 10 | 41 ± 13 | +27 | <0.005 |
Uninfected controls (×IO) | 75 ± 8 | 60 ± 15 | +20 | <0.007 |
- aMean ± SD of percentage of cell survival following 4–6 days incubation of PBMC in medium alone or with 100 µM SNAP.
- bIncreased apoptosis in cells incubated with SNAP compared to cells incubated in medium alone.
- cSignificance of SNAP effect on cell survival.