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Table 3 Correlation between l-NMMA-mediated inhibition of PBMC apoptosis and number of CD4+ cells in patients with AIDS

From: Critical Role of Nitric Oxide During the Apoptosis of Peripheral Blood Leukocytes from Patients with AIDS

PBMC from

Untreated

+l-NMMAa

Apoptosisb (%)

P c

AIDS <300 CD4+ cells/mm3 (×10)

59 ± 12

74 ± 9

−25

<0.003

AIDS >300 CD4+ cells/mm3 (×7)

56 ± 10

61 ± 11

−9

NS

Uninfected controls (×10)

75 ± 8

70 ± 12

+9

NS

  1. aMean ± SD of percentage of cell survival following 4–6 days incubation of PBMC in medium alone or with 500 µM l-NMMA.
  2. bDecreased apoptosis in cells incubated with l-NMMA compared to cells incubated in medium alone.
  3. cSignificance of l-NMMA effect on cell survival; NS, not significant.
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Molecular Medicine

ISSN: 1528-3658