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Fig. 6. | Molecular Medicine

Fig. 6.

From: RDP1258, a New Rationally Designed Immunosuppressive Peptide, Prolongs Allograft Survival in Rats: Analysis of Its Mechanism of Action

Fig. 6.

Immunohistochernical analysis of graft infiltrating cells. (A) Sections from heart allografts removed from untreated or RDP1258-treated recipients 5 days after transplantation were stained with anti-CD45 specific monoclonal antibodies (OX1 and OX30). A quantitative analysis of graft infiltrating cells from untreated (open bar) and RDP1258 treated recipients (stippled bar) (mean ± SD, n = 4) is shown; *p < 0.01. (B) Cryostat sections were stained with specific anti-rat monoclonal antibodies EDI (CD68); OX19 (CD5, pan-T); W3/25 (CD4); OX8 (CD8); OX33 (CD45RB, B cells); 3.2.3 (NKRP-1) and quantified as described in Materials and Methods. The percentage of area infiltrated (mean ± SD, n = 4) in untreated (open bars) and RDP1258-treated (stippled bars) is shown; *p < 0.01.

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Molecular Medicine

ISSN: 1528-3658