RDP1258, a New Rationally Designed Immunosuppressive Peptide, Prolongs Allograft Survival in Rats: Analysis of Its Mechanism of Action

Table 3 RDP1258 peptide effects on allograft survival

Treatment	Graft survival	Mean ± SEM
No treatment	5, 5, 6, 6, 6, 7, 7, 8, 8, 8	6.6 ± 0.6
RDP1258 5 mg/kg i.v. day −7, −1	5, 5, 5, 5, 6, 6	5.3 ± 0.2
RDP1258 5 mg/kg i.v. day −3	7, 7, 7, 8, 9, 14, 16	9.7 ± 1.4^a
RDP1258 1 mg/kg i.v. day −7, −1	5, 9, 9, 10, 12, 14, 19, 26, 32	15.1 ± 2.9^b
RDP1258 1 mg/kg i.v. day −1	8, 10, 12, 15, 16	12.2 ± 1
RDP1258 1 mg/kg i.p. day −7, −1	8, 9, 10, 13, 13, 14, 19, 19, 19, 20, 23, 27, >100, >100	16.2 ± 1.7^C
RDP1258 1 mg/kg i.p. day −7, −1 and ZnPP 20 mg/kg s.c. day 0	6, 6, 6, 6, 8, 11	7.2 ± 0.8^d
ZnPP 20 mg/kg s.c. day 0	7, 8, 13, 14	10.5 ± 1.8

^ap < 0.009 compared to RDP1258 5 mg/kg IV day −7, −1 group.
^bp < 0.0035 compared to untreated group.
^cp < 0.0008 compared to untreated group, taking out the two >100 days from the analyses.
^dp < 0.02 compared to RDP1258 1 mg/kg IP day −7, −1 group.