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Table 1 Spectrum of mutations in nickel sulfide-induced sarcomas

From: Reactive Oxygen-induced Carcinogenesis Causes Hypermethylation of p16Ink4a and Activation of MAP Kinase

Tumor

p16

p53

H and K-ras

P53NiS1

hypermethylation

deletion exon 5

none

C57NiS1

hypermethylation

A to C mutation in Intron 7 of p53

none

C57NiS2

hypermethylation

none

G to A in codon 12 of Ki-ras No H-ras mutations

C57NiS3

hypermethylation

none

none