From: Reactive Oxygen-induced Carcinogenesis Causes Hypermethylation of p16Ink4a and Activation of MAP Kinase
Tumor
p16
p53
H and K-ras
P53NiS1
hypermethylation
deletion exon 5
none
C57NiS1
A to C mutation in Intron 7 of p53
C57NiS2
G to A in codon 12 of Ki-ras No H-ras mutations
C57NiS3